Ruprecht-Karls-Universität Heidelberg

List of Publications

Selected journal articles

2016

  • Scheid LM, Mosqueira M, Hein S, Kossack M, Juergensen L, Mueller M, Meder B, Fink RH, Katus HA, Hassel D (2016)
    "Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress"
    Cardiovasc Res. 111(1):44-55
  • Forderer M, Georgiev T, Mosqueira M, Fink RH, Vogel M (2016)
    "Functional second harmonic generation microscopy probes molecular dynamics with high temporal resolution"
    Biomed Opt Express. 7(2):525-41
  • Schilling R, Fink RH, Fischer WB (2016)
    "Interaction of ions with the luminal sides of wild-type and mutated skeletal muscle ryanodine receptors"
    J Mol Model. 112(43):22(1):37
  • Cabello-Verrugio C, Ruiz-Ortega M, Mosqueira M, Simon F (2016)
    "Oxidative Stress in Disease and Aging: Mechanisms and Therapies"
    Oxid Med Cell Longev. 2016:8786564

2015

  • Georgiev T, Zapiec B, Forderer M, Fink RH, Vogel M (2015)
    "Colocalization properties of elementary Ca2+ release signals with structures specific to the contractile filaments and the tubular system of intact mouse skeletal muscle fibers"
    PJ Struct Biol. 192(3):366-375
  • Zapiec B, Mombaerts P. (2015)
    "Multiplex assessment of th positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography"
    Proc Natl Acad Sci U S A 112(43):E5873-82
  • Vogel M, Wingert A, Fink RH, Hagl C, Ganikhanov F, Pfeffer CP (2015)
    "Enabling the detection of UV signal in multimodal nonlinear microscopy with catalogue lens components"
    Journal of Microscopy 260(1):62-72
  • Georgiev T, Svirin M, Jaimovich E, Fink RH (2015)
    "Localized nuclear and perinuclear Ca(2+) signals in intact mouse skeletal muscle fibers"
    Frontiers Physiology 6:263
  • Most P, Ritterhoff J, Völkers M, Seitz A, Spaich K, Peppel K, Pleger S, Zimmermann W, Friedrich O, Fink RH, Koch W, Katus H, Gao E (2015)
    "S100A1 DNA-based inotropic therapy protects against pro-arrhythmogenic ryanodine receptor 2 dysfunction"
    Molecular Therapy 23(8):1320-1330
  • Llanos P, Contreras-Ferrat A, Georgiev T, Osorio-Fuentealba C, Espinosa A, Hidalgo J, Hidalgo C, Jaimovich E (2015)
    "The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice"
    Am J Physiol Endocrinol Metab. 308(4):294-305
  • Wieder N, Fink RH, von Wegner F (2015)
    "Exact Stochastic Simulation of a Calcium Microdomain Reveals the Impact of Ca2+ Fluctuations on IP3R Gating"
    Biophysical journal 108(3):557-567

2014

  • von Wegner F, Wieder N, Fink RH (2014)
    "Microdomain calcium fluctuations as a colored noise process"
    Frontiers in genetics 5:376
  • Yeo LL, Wieder N, Wang AS, Ting E, Rathakrishnan R, Soon D (2014)
    "Pearls & Oy-sters: A cause of intractable vomiting"
    Neurology 83(15):e141-144
  • Wang YT, Schilling R, Fink RH, Fischer WB (2014)
    "Ion-dynamics in Hepatitis C Virus p7 helical transmembrane domains - a molecular dynamics simulation study"
    Biophysical Chemistry 192:33-40
  • Buttgereit A, Weber C, Friedrich O (2014)
    "A novel quantitative morphometry approach to assess regeneration in dystrophic skeletal muscle"
    Neuromuscular disorders 24(7):596–603
  • Jin S, Kim J, Willert T, Klein-Rodewald T, Garcia-Dominguez M, Mosqueira M, Fink R, Esposito I, Hofbauer LC, Charnay P, Kieslinger M (2014)
    "Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1"
    Nature communications 5:3793
  • Schilling R, Fink RH, Fischer WB (2014)
    "MD simulations of the central pore of ryanodine receptors and sequence comparison with 2B protein from coxsackie virus"
    Biochimica et biophysica acta 1838(4):1122-1131

2013

  • Mosqueira M, Zeiger U, Förderer M, Brinkmeier H, Fink RH (2013)
    "Cardiac and respiratory dysfunction in Duchenne muscular dystrophy and the role of second messengers"
    Medicinal research reviews 33(5):1174-1213
  • Xu R, Andres-Mateos E, Mejias R, MacDonald EM, Leinwand LA, Merriman DK, Fink RH, Cohn RD (2013)
    "Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization"
    Experimental neurology 247:392-401
  • Mosqueira M, Baby SM, Lahiri S, Khurana TS (2013)
    "Ventilatory chemosensory drive is blunted in the mdx mouse model of Duchenne Muscular Dystrophy (DMD)"
    PLoS One 8(7):e69567
  • Wingert A, Seim H, Schürmann S, Fink RHA and Vogel M (2013)
    "Signal Efficiency in Gradient Index Lens Based Two Photon Microscopy"
    Open Journal of Biophysics 3(1A):43-50
  • Buttgereit A, Weber C, Garbe CS, Friedrich O (2013)
    "From chaos to split-ups – SHG microscopy reveals a specific remodelling mechanism in ageing dystrophic muscle"
    The Journal of Pathology 229(3):477-485

2012

  • Wagner S, Knipp S, Weber C, Hein S, Schinkel S, Walther A, Bekeredjian R, Müller OJ, Friedrich O (2012)
    "The heart in Duchenne muscular dystrophy: early detection of contractile performance alteration"
    Journal of cellular and molecular medicine 16(12):3028-3036
  • Elsing C, Georgiev T, Hübner CA, Boger R, Stremmel W, Schlenker T (2012)
    "Extracellular ATP induces cytoplasmic and nuclear Ca2+ transients via P2Y2 receptor in human biliary epithelial cancer cells (Mz-Cha-1)"
    Anticancer research 32(9):3759-3767
  • Mosqueira M, Willmann G, Zeiger U, Khurana TS (2012)
    "Expression profiling reveals novel hypoxic biomarkers in peripheral blood of adult mice exposed to chronic hypoxia"
    PLoS One 7(5):e37497
  • Seyler C, Duthil-Straub E, Zitron E, Gierten J, Scholz EP, Fink RH, Karle CA, Becker R, Katus HA, Thomas D. (2012)
    "TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation"
    British journal of pharmacology 165(5):1467-1475
  • Hong GS, Chen CP, Lin MH, Krüger J, Becker CF, Fink RH, Fischer WB. (2012)
    "Molecular dynamics simulations and conductance studies of the interaction of VP1 N-terminus from Polio virus and gp41 fusion peptide from HIV-1 with lipid membranes"
    Molecular membrane biology 29(1):9-25
  • von Wegner F, Wieder N, Fink RH (2012)
    "Simulation strategies for calcium microdomains and calcium-regulated calcium channels"
    Advances in experimental medicine and biology 740:553-567

2011

  • Wieder N, Fink RH, von Wegner F (2011)
    "Exact and Approximate Stochastic Simulation of Intracellular Calcium Dynamics"
    Journal of biomedicine & biotechnology 2011:572492
  • Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, von Wegner F, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P. (2011)
    "The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition"
    Circulation research 108(1):27-39

2010

  • Friedrich O, Fink RHA,  von Wegner F (2010)
    "New factors contributing to dynamic calcium regulation in the skeletal muscle triad - a crowded place"
    Biophysical Rev. 2(1):29-38
  • Schürmann S, von Wegner F, Fink RH, Friedrich O, Vogel M (2010)
    "Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils"
    Biophys J. 99(6):1842-51
  • Chen CP, Kremer C, Henklein P, Schubert U, Fink RHA, Fischer WB (2010)
    "Modulating the activity of the channel-forming segment of Vpr protein from HIV-1"
     Eur Biophys J. 39(7):1089-95. Epub 2009 Jul 24
  • von Wegner F, Fink RHA (2010)
    " Stochastic simulation of calcium microdomains in the vicinity of an L-type calcium channel"
    Eur Biophys J. 39(7):1079-88. Epub 2009 Jul 1
  • Fischer WB, Thiel G, Fink RH (2010)
    "Viral membrane proteins"
    Eur Biophys J . 39(7):1041-1042
  • Friedrich O., Both M., Weber C., Schürmann S., Teichmann M., v. Wegner F., Fink RHA., Vogel M., Chamberlaine JS., Garbe C (2010)
    "Microarchitecture is severely compromised but motor protein function preserved in dystrophic mdx skeletal muscle"
    Biophys J. 98(4):606-616

2009

  • Friedrich O., Fink RHA.,  v. Wegner F. (2009)
    "New factors contributing to dynamic calcium regulation in the skeletal muscle triad - a crowded place"
    Biophysical Rev. 2(1):29-38
  • Friedrich O., Hund E., v Wegner F. (2009)
    "Enhance muscle shortening and impaired Ca(2+) channel function in an acute septic myopathy model"
    J. Neurol. 257(4):546-55
  • Chen C.P., Kremer C., Henklein P., Schubert U., Fink R.H.A., Fischer W.B. (2009)
    "Modulating the activity of the channel-forming segment of Vpr protein from HIV-1"
    Eur Biophys J. 39(7):1089-95
  • Friedrich O. (2009).
    "Muscle function and high hydrostatic pressures. Cellular mechanisms and implications for taxonomic environmental locomotion". Comparative High Pressure Biology. P. Sebert (ed.), Science Publishers Inc., Enfield, USA in press
  • v Wegner F, Schürmann S, Fink RHA, Vogel M & O Friedrich (2009).
    "Motor protein function in skeletal muscle - a multiple scale approach."
    IEEE Trans Med Imaging
    28(10):1632-42
  • Launikonis BS, Stephenson DG & O Friedrich (2009).
    "Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle."
    J Physiol 587(10): 2299-2312.
  • v. Wegner F., Fink RHA, (2009)
    "Stochastic simulation of calcium microdomains in the vicinity of an L-type calcium channel".
    Eur Biophys J
    , 39(7):1079-88

2008

  • Friedrich O. (2008).
    Critical illness myopathy: sepsis-mediated failure of the peripheral nervous system.
    Eur J Anaesthesiol 42: 73-82
  • v. Wegner F., Ober T, Weber C, Schürmann S, Winter R, Friedrich O, Fink RHA, Vogel M. (2008)
    "Velocity distributions of single F-actin trajectories from fluorescence image series using trajectory reconstruction and optical flow mapping".
    Journal of Biomedical Optics
    , 13 (5), 054018
  • Teichmann MDH, v Wegner F, Fink RHA, Chamberlain JS, Launikonis BS, Martinac B & O Friedrich (2008).
    Inhibitory control of Ca2+-sparks via mechanosensitive channels is disrupted in dystrophin-deficient muscle but restored by mini-dystrophin expression.
    PLoS One 3(11): e3644.
  • Heinzel FR, Bito V, Biesmans L, Wu M, Detre E, von Wegner F, Claus P, Dymarkowski S, Maes F, Bogaert J, Rademakers F, D'hooge J, Sipido K. (2008)
    "Remodeling of T-tubules and reduced synchrony of Ca2+ release in myocytes from chronically ischemic myocardium."
    Circ Res. 102(3), 338-46
  • Hassel*, D., Trano*, N., Scholz*, E., Rauch, G.-J., Friedrich, O. , Just, S., Seemann, G., Zitron, E., Marquart, S., Karle, C., Dössol, O., Katus, H.A., Fishman, M.C. & W. Rottbauer (2008). Deficient zERG channel gating causes short QT syndrome in zebrafish reggae mutants.
    Circulation 117(7), 866-875
  • Schnee, S., v Wegner, F., Schürmann, S., Ludwig, H., Fink, R.H.A., Friedrich, O. (2008)
    "Microdomain Ca2+ dynamics in mammalian muscle following prolonged high pressure treatments".
    Journal of Physics Conf. Ser.
    , 121, 112003.
  • Zink, W., Kaess, M., Hofer, S., Plachky, J., Zausig, Y., Sinner, B., Weigand, M., Fink, R.H.A., Graf, B. (2008)
    "Alterations in intracellular Ca2+-homeostasis of skeletal muscle fibers during sepsis"
    Critical Care Medicine 36(5), 1559-1563
  • Friedrich*, O., v Wegner*, F., Chamberlain, J.S., Fink, R.H.A. & P. Rohrbach (2008).
    "L-type Ca2+ channel function is linked to dystrophin expression in mammalian muscle."
    PLoS ONE
    3(3): e1762.
  • v Wegner, F., Koyama, S., Miwa, T. & O. Friedrich (2008).
    "Resting membrane potentials recorded on-site in intact skeletal muscles from deep sea fish (Sigmops gracile) salvaged from depths up to 1.000 m"
    Marine Biotechnology, 10(4), 478-86
  • Friedrich, O., Weber, C., v Wegner F., Chamberlain, J.S. & R.H.A. Fink, R.H.A. (2008).
    "Unloaded speed of shortening in voltage-clamped intact skeletal muscle fibers from wt, mdx and transgenic mini-dystrophin mice using a novel high-speed acquisition system."
    Biophysical Journal
    , 94, 4751-4765.

2007

  • v Wegner, F., Ober, T., Weber, C., Friedrich, O., Fink, R.H.A. (2007)
    "Multiresolution transform denoising and segmentation single of single molecule motility image series"
    Proc Spie, 6626, 66260Q
  • Vogel,M., Ober, T., Friedrich O., v Wegner, F., Schürmann, S., Weber, C., Fink, R.H.A. (2007)
    "Tuning of molecular motors in muscle contraction"
    Vienanno 07 2: 105-110.
  • Völkers M, Loughrey CM, MacQuaide N, Remppis A, deGeorge B, Koch WJ, v Wegner F, Friedrich O, Fink RHA, Smith G & P Most (2007).
    S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes.
    Cell Calcium 41: 135-143.
  • Schürmann, S., Weber, C., Fink, R.H.A., Vogel, M. (2007)
    "Myosin rods are a source of second harmonic generation signals in skeletal muscle"
    Proc SPIE 6442: 64421U
  • v Wegner, F., Both, M., Fink, R.H.A., Friedrich, O. (2007)
    "Fast XYT imaging of elementary calcium releas events in muscle with multifocal multiphoton microscopy and wavelet denoising and detection"
    IEEE Trans. Med. Imaging 26(7), 925-934
  • Friedrich, O., v Wegner, F., Wink, M., Fink, R.H.A. (2007)
    "Na+ and K+ channels as molecular targets of the alkaloid ajmaline in skeletal muscle fibres"
    Br. J. Pharmacol. 151: 63-74.

2006

  • Gaul, S., Ozsarac, N., Lu, L., Fink, R.H.A., Gage, P. (2006)
    "The neuroactive steroids alphaxolone and pregnanolone increase the conductance of single GABAA channels in newborn rat hippocampal neurons"
    J. Ster. Biochem. Mol. Biol., 104, 35-44
  • Friedrich, O.,Hund E. (2006)
    "Critical illness myopathy bei Intensivpatienten: Pathogenetische Konzepte und klinisches Management"
    Der Anästhesist 55: 1271-1280
  • Friedrich, O., v Wegner, F., Wink, M, Fink, R.H.A. (2006)
    "Na+ and K+ channels as molecular targets of the alkaloid ajmaline in skeletal muscle fibres"
    Br. J. Pharmacol. 151(1) 63-74
  • Friedrich, O., Wegner, F.V., Hartmann, M., Frey, B., Sommer, K., Ludwig, H., Fink, R.H.A. (2006)
    "'In situ' high pressure confocal Ca(2+)-fluorescence microscopy in skeletal muscle: a new method to study pressure limits in mammalian cells"
    Undersea Hyperb.Med.33(3):181-195
  • v Wegner, F. Both, M., Fink, R.H.A., Friedrich, O. (2006)
    "Elementary calcium release events in mammalian skeletal muscle: effects of the anesthetic drug thiopental"
    J. Muscle Res. Cell Mot.27: 315-326.
  • Völkers, M., Loughrey, C.M., MacQuaide, N., Remppis, A., de George, B., Koch, W.J., v Wegner, F., Friedrich, O., Fink, R.H.A., Smith, G., Most, P. (2006)
    "S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes"
    Cell Calcium 41 (2):135-143
  • Rohrbach, P., Sanchez C.P., Hayton, K., Friedrich, O., Patel, J.,Singh Sidu A.B., Ferdig, M.T., Fidock, D.A., Lanzer, M. (2006)
    "Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum"
    EMBO J. 25:3000-3011
  • Kawai, M., Kido, T., Vogel, M., Fink, R.H.A., Ishiwata, S. (2006)
    "Temperature change does not affect force between regulated actin filaments and HMM in single molecule experiments"
    J. Physiol. 574 (3) :877-887
  • v.Wegner, F., Both, M., Fink, R.H.A., Friedrich, O. (2006)
    "3D high-speed multifocal multiphoton microscopy in muscle and wavelet analysis of fast elementary calcium release events"
    IEEE ISBI 2006 Proceedings : 1148-1151.
  • Friedrich, O. (2006)
    "Critical Illness Myopathy: what is happening ?"
    Current Opinion in Nutrition & Metabolic Care 9: 403-409.
  • Sinner, B., Friedrich, O., Zink, W., Fink, R.H.A. & B.M. Graf (2006)
    "GABAmimetic intravenous anaesthetics inhibit spontaneous Ca2+ oscillations in cultured hippocampal neurons."
    Acta Anesthesiologica Scandinavia 50:742-748.
  • Vogel*, M., Hahn*, D., Schürmann, S., Lang, M., v.Wegner, F., Friedrich, O., Engelhardt J., Hell, S.W. & R.H.A. Fink (2006)
    "4Pi-SHG imaging of mammalian myofibrillar structures"
    Proc. SPIE 6089, 60891Q
  • Vogel*, M., Schürmann*, S., Friedrich, O., v Wegner, F., Both*, M. & R.H.A. Fink (2006)
    "Scanning multi photon microscopy of SHG signals from single myofibrils of mammalian skeletal muscle"
    Proc SPIE 6089, 60891 J
  • v.Wegner*, F., Both*, M. & R.H.A. Fink (2006)
    "Automated detection of elementary calcium release events using the 'a trous' wavelet transform"
    Biophysical Journal 90:2151-2163
  • O. Friedrich, K.R. Kress, M. Hartmann, B. Frey, K. Sommer, H. Ludwig & R.H.A. Fink (2006)
    "Prolonged high pressure treatments in mammalian skeletal muscle result in loss of functional sodium channels and altered calcium channel kinetics."
    Cell Biochemistry Biophysics 45 (1): 71-83

2005

  • V. Askoxylakis, S. Zitzmann, W. Mier, K. Graham, S. Krämer, F. v. Wegner, R.H.A. Fink, M. Schwab, M. Eisenhut & U. Haberkorn (2005)
    "Preclinical evaluation of the breast cancer cell binding peptide p160"
    Clinical Cancer Research 11(8):6706-6712
  • Rohrbach*, P., Friedrich, O.*, Hentschel, J., Plattner, H., Fink, R.H.A. & M. Lanzer (2005)
    "Quantitative calcium measurements in subcellular compartments of P. falciparum-infected erythrocytes."
    J. Biol. Chem. 280(30):27960-27967
  • Zink, W., Missler, G.M.S., Sinner, B., Martin, E., Fink, R.H.A. & B.M. Graf (2005)
    "Differential Effects of Bupivacaine and Ropivacaine Enantiomers on Intracellular Ca2+ Regulation in Murine Skeletal Muscle Fibers."
    Anesthesiology 102(4):793-798.
  • O. Friedrich, R.H.A. Fink & E. Hund (2005)
    "Understanding Critical Illness Myopathy (CIM): approaching the pathomechanism."
    Journal of Nutrition 135:1813S-1817S
  • B. Sinner, O. Friedrich, W. Zink, E. Martin, R.H.A. Fink, & B. Graf (2005)
    "Ketamine stereoselectively inhibits spontaneous Ca2+-oscillations in cultured hippocampal neurons"
    Anesthesia & Analgesia 100: 1660-1666.
  • M. Weber, L.Motin, S. Gaul, F. Beker, R.H.A. Fink & D.J. Adams (2005)
    "Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca2+ transients in rat intracardiac ganglion neurons"
    British Journal of Pharmacology 144: 98-107

2004

  • F. Nolte, O. Friedrich, M. Rojewski, R.H.A. Fink, H. Schrezenmeier & S. Körper (2004)
    "Depolarization of the plasma membrane in the arsenic trioxide-(As203) and anti-CD95-induced apoptosis in myeloid cells"
    FEBS Letters 578: 85-89.
  • S. Nessler*, O. Friedrich*, N. Bakouh, R.H.A. Fink, C.P. Sanchez, G. Planelles, M. Lanzer (2004)
    "Evidence for activation of endogenous transporters in Xenopus laevis oocytes expressing the P. falciparum chloroquine resistance transporter PfCRT"
    Journal of Biological Chemistry 279(38): 53-65
  • R. Wagner, R.H.A. Fink & D.G. Stephenson (2004)
    "Effects of chlorpromazine on excitation-contraction coupling events in fast-twitch skeletal muscle fibres  of the rat"
    British Journal of Pharmacology 141:624-633
  • Friedrich, O., Hund, E., Hacke, W., R.H.A. Fink (2004)
    "Critical Illness Myopathy (CIM): Evidence for a myotoxic low molecular weight factor in the serum of patients after severe SIRS"
    In: Proc 6th World Congress on Trauma, Shock, Inflammation & Sepsis: Pathophysiology, Immune Consequences and Therapy. Eugen Faist (Ed.), Medimond International Proceedings, 269-272
  • M . Both, M. Vogel, O. Friedrich, F. v. Wegner, T. Künsting, R.H.A. Fink, D. Uttenweiler (2004)
    "Second harmonic imaging of intrinsic signals in muscle fibers in situ"
    Journal of Biomedical Optics, 9(5): 882-892
  • Friedrich, O., Both, M., Gillis, J.M., Chamberlain, J.S., R.H.A. Fink (2004)
    "Mini-Dystrophin restores L-type calcium currents in skeletal muscle of transgenic mdx mice"
    Journal of Physiology 555.1: 251-265.
  • Friedrich, O., Hund, E., Weber, C., Hacke, W., R.H.A. Fink (2004)
    "Critical Illness Myopathy serum fractions affect membrane excitability and intracellular calcium release in mammalian skeletal muscle"
    Journal of Neurology 251: 53-65

2003

  • M. Both, M. Vogel, R.H.A. Fink, D. Uttenweiler (2003)
    "Second harmonic generation imaging in muscle fibers"
    Proc. SPIE 5139:112-120.
  • Stephan Schmitz, Christoph J. Schankin, Heino Prinz, Rachel S. Curwen, Peter D. Ashton, Leo S. D. Caves, Rainer H. A. Fink, John C. Sparrow, Peter J. Mayhew, and Claudia Veigel (2003)
    "Molecular Evolutionary Convergence of the Flight Muscle Protein Arthrin in Diptera and Hemiptera"
    Mol Biol Evol 20: 2019-2003.[Abstract] [Full Text] [PDF] 
  • Zink, W., Seif, C., Bohl, J.R.E., Hacke, N., Braun, P.M., Sinner, B., Martin, E., Fink, R.H.A., Graf, B.M. (2003)
    "The acute myotoxic effects of bupivacaine and Ropivacaine after continuous peripheral nerve blockades"
    Anesth Analg 97: 1173-1179
  • Friederike Beker, Martin Weber, Rainer H.A. Fink and David J. Adams (2003)
    "Muscarinic and nicotinic ACh receptor activation differentially mobilize Ca2+ in rat intracardiac neurons"
    Journal of Neurophysiology 90: 1956-1964. [Abstract]
  • Patrick Most, Andrew Remppis, Cornelia Weber, Juliane Bernotat, Philipp Ehlermann, Sven T. Pleger, Wolfgang Kirsch, Martin Weber, Dietmar Uttenweiler, Godfrey L. Smith, Hugo A. Katus, and Rainer H.A. Fink (2003)
    "The C-terminus (aa 75-94) and the linker region (aa 42-54) of the Ca2+ binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibres"
    J. Biol. Chem. 278: 26356-26364 [Abstract]
  • D. Uttenweiler, M. Both, W. Zink, B.Sinner, E. Martin, B.M. Graf, R.H.A. Fink (2003)
    "High resolution fluorescence microscopy in combination with mathematical modelling. First evidence of sub-cellular anesthetic effects on Ca2+ sparks in situ"
    Anaesthesist 52: 162-168.
  • Uttenweiler, D., Weber, C., Jaehne, B., Fink, R.H.A. & Scharr, H. (2003)
    "Spatiotemporal anisotropic diffusion filtering to improve signal-to-noise ratios and object restoration in fluorescence microscopic image sequences"
    J. Biomed. Opt. 8: 40-47.

2002

  • Uttenweiler, D., Kirsch, W.G., Schulzke, E., Both, M. & Fink, R.H.A. (2002)
    "Model based analysis of elementary Ca2+-release events in skinned mammalian skeletal muscle fibres"
    Eur. Biophys. J. 31: 331-340.
  • Ruegg , C. , Veigel, C., Molloy, J.E., Schmitz, S., Sparrow, J.C., Fink, R.H.A. (2002)
    "Molecular  Motors: Force and Movement Generated by Single Myosin II Molecules"
    News Physiol. Sci. 17:213-218 [Abstract]
  • Raisch, F., Scharr, H., Kirchgeßner, N., Jähne, B., Fink, R.H.A. & Uttenweiler, D. (2002) "Velocity and feature estimation of actin filaments using active contours in noisy fluorescence image sequences"
    Proc. 2nd IASTED Int. Conf. Visualization, Imaging and Image Processing, 645-650.
  • Friedrich, O., Kress, K.R., Ludwig, H. & Fink, R.H.A. (2002) "Membrane Ion Conductances of Mammalian Skeletal Muscle in the Post-Decompression State after High-Pressure Treatment"
    J.Membrane Biol.188: 1-12.
  • Zink, W., Graf, B.M., Sinner, B., Martin, E., Fink, R.H.A. & Kunst, G. (2002) "Differential effects of bupivacaine on intracellular Ca2+ regulation - potential mechanismus of its myotoxicity"
    Anesthesiology 97: 710-716.

2001

  • Kirsch, W.G., Uttenweiler, D. & Fink, R.H.A. (2001) "Spark- and ember-like elementary Ca2+ release events in skinned fibres of adult mammalian muscle"
    J. Physiol. 537.2: 379-389.
  • Kress, K.R., Friedrich, O., Ludwig, H. & Fink, R.H.A. (2001) "Reversibility of high pressure effects on the contractility of skeletal muscle"
    J. Muscle Res. Cell Motil. 22(4):379-389.
  • Scharr, H. & Uttenweiler, D. (2001) "3D Anisotropic Diffusion Filtering for Enhancing Noisy Actin Filament Fluorescence Images" Lecture Notes in Computer Science 2191: 69-75.
  • Friedrich, O., Ehmer, T., Uttenweiler, D., Vogel, M., Barry, P.H. & Fink, R.H.A. (2001) "Numerical Analysis of Ca2+ Depletion in the Transverse Tubular System (TTS) of Mammalian Muscle"
    Biophysical J. 80(5): 2046-2055. [Abstract][PDF Full text]

2000

  • Knobloch, U., Vogel, M. & Fink, R.H.A. (2000) "A new transducer based on the evanescent field for high resolution displacement and force measurements"
    Pfluegers Arch - Eur J Physiol 441(1): 32-38.
  • Kunst, G., Stucke, A.G., Graf, B.M., Martin, E. & Fink, R.H.A.(2000) "Desflurane induces only minor Ca2+ Release from the Sarcoplasmic Reticulum of Mammalian Skeletal Muscle"
    Anesthesiology 93: 832-836.
  • Uttenweiler, D., Veigel, C., Steubing, R., Goetz, C., Mann, S., Haußecker, H., Jaehne, B. & Fink, R.H.A. (2000) "Motion determination in actin filament fluorescence images with a spatio-temporal orientation analysis method"
    Biophysical J. 78(5): 2709-2715. [Abstract][Full Text]
  • Kunst, G., Kress, K.R., Gruen, M., Uttenweiler, D., Gautel, M. & Fink, R.H.A. (2000) "Myosin Binding Protein C, a Phosphorylation-Dependent Force Regulator in Muscle That Controls the Attachment of Myosin Heads by Its Interaction With Myosin S2."
    Circ. Res. 86: 51-58. [Abstract]
  • Cremer T, Kreth G, Koester H, Fink RH, Heintzmann R, Cremer M, Solovei I, Zink D, Cremer C. (2000) "Chromosome territories, interchromatin domain compartment, and nuclear matrix: an integrated view of the functional nuclear architecture"
    Crit Rev Eukaryot Gene Expr. 10(2):179-212.

1999

  • Haarmann, C.S., Fink, R.H.A. & Dulhunty, A.F. (1999) "Oxidation and Reduction of Pig Skeletal Muscle Ryanodine Receptors."
    Biophys. J. 77(6): 3010-3022. [Abstract][Full Text]
  • Stegmann, H. & Fink, R.H.A. (1999) "A combined solution exchange/plunge freezing device for skinned muscle fibers."
    J. Muscle Res. Cell Motil. 20(5): 497-503.
  • Stegmann, H., Wepf, R., Schröder, R.R. & Fink, R.H.A. (1999) "Quantification of total calcium in terminal cisternae of skinned muscle fibers by imaging electron energy-loss spectroscopy."
    J. Muscle Res. Cell Motil. 20(5): 505-515.
  • Friedrich, O., Ehmer, T. & Fink, R.H.A. (1999) "Calcium currents during contraction and shortening in enzymatically isolated murine skeletal muscle fibres."
    J. Physiol. 517.3: 757-770.
  • Kunst, G., Graf, B. M., Schreiner, R., Martin, E. & Fink, R.H.A. (1999) "Differential Effects of Sevoflurane, Isoflurane and Halothane on Ca 2+-Release from the Sarcoplasmic Reticulum of Skeletal Muscle."
    Anesthesiology 91: 179-86.

1998

  • Körper, S., Wink, M. & Fink, R.H.A. (1998) "Differential effects of Alkaloids on sodium currents of isolated single skeletal muscle fibers." FEBS Letters 436 :251-255. [Abstract][Full Text]
  • Uttenweiler, D., Weber, C. & Fink, R.H.A. (1998) "Mathematical Modlling and Fluorescence Imaging to Study the Ca2+ -turnover in Skinned Muscle Fibres."
    Biophys J. 74: 1640-1653. [Abstract][Full Text]
  • Veigel, C., von Maydell, R.D., Kress, K.R., Molloy J.E. & Fink, R.H.A. (1998) "The effect of ionic strength on the kinetics of rigor development in skinned fast-twitch skeletal muscle fibres."
    Pfluegers Arch. - European Journal of Physiology 435: 753-761. [Abstract][Full Text]

1997

  • Uttenweiler, D., Veigel, C., Weber, C. & Fink, R.H.A. (1997) "Studying the sarcoplasmic reticulum of muscle with fluorescence imaging and numerical simulations."
    Bioforum 4: 161-164.

1996

  • Uttenweiler, D., Veigel, C. & Fink, R.H.A. (1996) "Fluorescence imaging and microscopic laser applications provide new tools to analyze Ca2+-regulation in muscle."
    Bioforum 11: 480-485.
  • Fink, R.H.A. & Veigel, C. (1996) "Calcium uptake and release modulated by counter-ion conductances in the sarcoplasmic reticulum of skeletal muscle."
    Acta Physiol. Scand. 156: 387-396.
  • Makabe, M., Werner, O. & Fink, R.H.A. (1996) "The contribution of the sarcoplasmic reticulum Ca2+-transport-ATPase to caffeine induced Ca2+-transients of murine skeletal muscle fibres."
    Pfluegers Arch - Eur J Physiol 432: 717-726.

1995

  • Veigel, C., von Maydell, R., Wiegand-Steubing, R., Goody, R. & Fink, R.H.A. (1995) "The influence of ionic strength upon relaxation from rigor induced by flash photolysis of caged-ATP in skinned murine skeletal muscle fibres."
    Pfluegers Arch - Eur J Physiol 430: 994-1003.
  • von Maydell, R., Veigel, C., Wiegand-Steubing, R., Uttenweiler, D. & Fink, R.H.A. (1995) "Muscle relaxation: Kinetics study with flash photolytic liberation of ATP."
    Bioforum 18: 443-447.
  • Uttenweiler, D., Wojciechowski, R., Makabe, M., Veigel, C. & Fink, R.H.A. (1995) "Combined analysis of intracellular calcium with dual excitation fluorescence photometry and imaging."
    Opt. Eng. 34: 2864-2871.

1994

  • Veigel, C., von Pfeil, D., Harim, A. & Fink, R.H.A. (1994) "Contractile properties of myofibrillar bundles and fusion of sarcolemma vesicles of normal and deseased skeletal muscle using UV-laser microbeam dissection and IR-optical trapping."
    SPIE Biomedical and Optoelectronic Devices and Systems 2328 : 174-1 85.
  • Uttenweiler, D., Wojciechowski, R., Makabe, M., Veigel, C. & Fink, R.H.A. (1994) "A combined system for high time resolution dual excitation fluorescence photometry and fluorescence imaging of calcium transients in single normal and diseased skeletal fibres." SPIE Biomedical and Optoelectronic Devices and Systems 2328:133-143.
  • Veigel, C., Wiegand Steubing, R., Harim, A., Weber, C., Greulich, K.O. & Fink, R.H.A. (1994) "New cell biological applications of the laser microbeam technique: The microdissection and skinning of muscle fibers and the perforation and fusion of sarcolemma vesicles."
    Eur. J. Cell Biol. 63: 140-148.

Top

Articles in Books

  • O.Friedrich "Das Erste Kompakt: Physiologie", Springer
  • O. Friedrich, K.R. Kress, H. Ludwig and R.H.A. Fink (2003) "Activation of Na+ and L-Type Ca2+ Currents in Muscle is More Susceptible to Prolonged High Pressure Treatments than Voltage-dependent Inactivation", in Advances in High Pressure Biosciences and Biotechnology II, Ed. R. Winter. Springer, 241-246
  • Uttenweiler, D. & Fink, R.H.A. (2000) "Model based fluorescence imaging", in Computer Vision and Applications, Eds. B. Jähne & H. Haussecker. Academic Press, 658-659.
  • Uttenweiler, D. & Fink, R.H.A. (2000) "Analysis of Motility Assay Data", in Computer Vision and Applications, Eds. B. Jähne & H. Haussecker. Academic Press, 642-643.
  • Fink, R.H.A., Gillis, J.M., Perricaudet, M. (1999) "Pathogenesis of Membrane Damage in Duchenne Muscular Dystrophy (DMD)", in Biomedical and Health Research Programme 1994-98 - Summaries of research projects supported under BIOMED 2, Vol. II, Office for Official Publications of the European Communities, 206-207.
  • Uttenweiler, D. & Fink, R.H.A. (1999) "Mathematical modelling of Ca2+-transients measured with fluorescence imaging",  in Handbook of Computer Vision and Applications, Vol.3, Eds. B. Jähne, H. Haußecker & P. Geißler, Academic Press, 737-750.
  • Uttenweiler, D. & Fink, R.H.A. (1999) "Dynamic fluorescence imaging", in Handbook of Computer Vision and Applications, Vol.1, Eds. B. Jähne, H. Haußecker P. Geißler, Academic Press, 323-346.
  • Kress, K.R., Friedrich, O. & Fink, R.H.A. (1999) "Reversibility of high pressure effects in isolated adult murine skeletal muscle fibres tested at pressures up to 600 bar and a temperature of +4° C", in Advances in High pressure bioscience and biotechnology, Ed. H. Ludwig, Springer Verlag, 551-554.
  • Sandkühler, J., Fink, R.H.A. & Lux, W. (1992) "From ion channel to neuronal network: Computer aided physiology teaching to advanced medical and science students." (in German)
    In: Animal protection through alternatives (Tierschutz durch Alternativen)
    Documentation volume, Verlag Gesundheit GmbH, ed. Hardegg, pp. 274-276.
  • Veigel, C. & Fink, R.H.A. (1992) "Zellphysiologisches Praktikum zum molekularen Verständnis von elektrischen Membranvorgängen und kontraktiler Aktivierung." ibidum, pp. 293-297.
  • Fink, R.H.A. & Stephenson, D.G. (1982) "Effects of 4-aminopyridine on isometric force (Ca++)- relations in mammalian slow and fast twitch skinned muscle fibres."
    In: Aminopyridines and similarly acting drugs. Effects on nerves, muscles and synapses. Bowman , W.C., Lechat, P., Thesleff, P., eds.
    Advances in the Biosciences, 35:275. Pergamon Press.